Hiroyuki Moriuchi
- Professom, Division of Medical Virology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences
- Pediatrics, Virology, Infectious Diseases
- 1）Epidemiological and clinical studies (especially antiviral therapy) on congenital cytomegalovirus infection
2）Prevention of mother-to-child transmission of human T-cell leukemia virus type I
3）Studies on mother-to-child infections (e.g., rubella, hepatitis B) in a birth cohort in Vietnam
4）Effects of co-infection with non-pathogenic viruses on HIV-infected individuals in Thai HIV cohort
Not knowing whether it is a living organism or not, “virus” can affect its host in a variety of ways. It is quite a subject of scientific interest as well as a target of clinical challenge. We were wondering why the same virus could cause avirulent postnatal infection and virulent intrauterine infection, why only a small portion of carriers would develop virus-associated diseases while most carriers remain asymptomatic for life, and by what mechanism coinfection of apparently avirulent viruses could modify the pathogenesis of virulent viruses such as HIV and improve prognosis of infected individuals. If our research could lead to the answers, they would be directly translated into clinical solutions.
▼Course List
Medical Virology Seminar I ? IV
Medical Virology Practice I ? II
Medical Virology Thesis Research I - II
▼Recommended books
Fields Virology (Knipe, Fields Virology)
David M. Knipe , Peter Howley▼Homepage
http://www.med.nagasaki-u.ac.jp/peditrcs/
personal history
2000.4 to date Professor in the Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences
1/1999 to date Chairman and Professor in the Department of Pediatrics, Nagasaki University School of Medicine, Japan
1998.4-1999.1 Staff Scientist in the Laboratory of Immunoregulation (Chief: Anthony S. Fauci, M.D.), NIAID, NIH
1998.1-1998.12 Visiting Physician in the Department of Infectious Diseases, Children’s National Medical Center, Washington, D. C. (Chairman: William Rodrigues, M.D., Ph.D.)
1995.7-1998.12 Clinical Staff in NIAID, NIH
1995.7-1998.3 Research Associate in the Laboratory of Immunoregulation, NIAID
1994.7-1997.6 Clinical Associate (Infectious Diseases Fellowship Program) (Director: John Bennett, M.D.), NIAID, NIH
1994.2-1994.6 Visiting Associate in Medical Virology Section (Head: Stephen E. Straus, M.D.), Laboratory of Clinical Investigation, NIAID, NIH
1990.12-1994.1 Visiting Fellow in Medical Virology Section, LCI, NIAID, NIH
1988.6-1990.12 Research Fellow in Virus Laboratory (Head: Yoshio Numazaki, M.D.), Sendai National Hospital, Japan
1986-1988 Medical Staff in Pediatrics, Sasebo Kyosai Hospital, Japan
1984-1985 Resident in Pediatrics (Professor and Head: Yoshiro Tsuji, M.D.), Nagasaki University School of Medicine, Japan
works/thesis
1. Moriuchi H, Doi H, Masuzaki H, Katamine S. Mother-to-child transmission of human T-cell leukemia virus type I. Pediatr Infect Dis J. 2013 (in press).
2. Koyano S, Inoue N, Oka A, Moriuchi H, et al. Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper: feasibility and outcomes from a multicenter study. BMJ Open 2011;1:000118.
3. Tagawa M, Tanaka H, Moriuchi M, Moriuchi H. Retrospective diagnosis of congenital cytomegalovirus infection at a school for the deaf by using preserved dried umbilical cord. J Pediatr. 2009;155:749-51.
4. Moriuchi M, Moriuchi H. Cell-Type-Dependent Effect of Transforming Growth Factor-s, a Major Cytokine in Breast Milk, on Human Immunodeficiency Virus Type 1 Infection of Mammary Epithelial MCF-7 Cells or Macrophages. J Virol. 2004;78:13046-52.
5. Moriuchi H, Moriuchi M, Fauci AS. Factors secreted by HTLV-I infected cells can enhance or inhibit replication of HIV-1 in HTLV-I uninfected cells: implication for in vivo coinfection with HTLV-I and HIV-1. J Exp Med. 1998;187:1689-98.